Our lab focusses on understanding the underlying mechanisms of cell and tissue response to radiation. To gain a better understanding of the mechanisms, we combine Monte Carlo simulations of radiation induced damages on sub-cellular targets followed by mechanistic modeling of DNA repair kinetics with radiobiology experiments.

Monte Carlo Simulations

We pursue Monte Carlo (MC) simulations at various scales:

TOPAS:

The TOol for PArticle Simulations (TOPAS) has been developed over the past decade (Perl et al. 2012). TOPAS provides macroscopic MC simulations in patient geometries and treatment delivery systems.

1. Perl J, Shin J, Schuemann J, Faddegon B, Paganetti H. TOPAS: an innovative proton Monte Carlo platform for research and clinical applications. Med. Phys. 2012 Nov;39(11):6818–37. PMCID: PMC3493036

TOPAS-nBio

TOPAS-nBio is awesome.